Saturday, August 10, 2013

Save Us From Misleading Press Releases


Exposure to subliminal cues can help us choose the apple instead of the cake. Or can it...  Let's take a look.

Our Brains Can (Unconsciously) Save Us from Temptation

Aug. 8, 2013 — Inhibitory self control -- not picking up a cigarette, not having a second drink, not spending when we should be saving -- can operate without our awareness or intention.

That was the finding by scientists at the University of Pennsylvania's Annenberg School for Communication and the University of Illinois at Urbana-Champaign. They demonstrated through neuroscience research that inaction-related words in our environment can unconsciously influence our self-control. Although we may mindlessly eat cookies at a party, stopping ourselves from over-indulging may seem impossible without a deliberate, conscious effort. However, it turns out that overhearing someone -- even in a completely unrelated conversation -- say something as simple as "calm down" might trigger us to stop our cookie eating frenzy without realizing it.

The press release states that overhearing a message of restraint in a background conversation might prevent us from reaching for a second piece of cake at the holiday party. What's the evidence for this?

A study by Hepler and Albarracin (2013) recorded EEG activity (brain waves) while 20 participants performed a "go/no-go" task that tests their inhibitory control abilities. The subjects responded every time they saw an "X" on the screen but refrained from responding when they saw a "Y". These target letters were preceded by a visual masking stimulus (&&&&&&) for 16.7 msec, a subliminal prime word for 33.4 msec, and then another masking stimulus (&&&&&&) for 50.1 msec. The idea here is to show the prime word very briefly and to "mask" conscious perception of the word.

The prime words were general action words (go, run, move, hit, start), general inaction words (still, sit, rest, calm, stop), and control stimuli (scrambled action and inaction prime words – e.g., rnu). One obvious hypothesis would be that exposure to the masked inaction words would make you better at inhibiting a response to "Y". The authors didn't exactly say that, instead predicting that the amplitude of the P3 component extracted from averaged EEG on no-go trials would reflect the engagement of unconscious inhibitory processes.

However, if behavior is unaffected by the masked inaction words, it ultimately doesn't matter what happens to the P3 component. There is nothing you can say about "resisting temptation" -- behavioral change is not the same thing as a change in the size of the P3 component. The latter may indicate that a subject's brain registered sit, rest, calm, or stop implicitly, but this neural activity wasn't enough to improve stopping ability.

And in fact, this is exactly what the study demonstrated. The masked primes had a modest effect on the size of the P3 wave to the subsequent no-go stimulus, which reached its peak at around 400 msec post-stimulus (i.e., less than half a second after the "Y"). The inaction primes were significantly different from the action primes, but neither one differed from the neutral condition.1


Fig. 1. (Hepler & Albarracin, 2013). Grand average waveforms at electrode Cz to correct no-go trials in Experiment 1. 


The authors interpreted this effect to indicate that inhibition processes were "engaged" by the subliminal primes.

However, the primes had absolutely no impact on how well participants could resist responding to the no-go stimuli [F(2, 38) = .00, p = .99]. Accuracy in the inaction prime condition was exactly the same as in the action prime condition. In other words, the study showed that Our Brains Cannot (Unconsciously) Save Us from Temptation.

Or as succinctly stated by Justin Kiggins on Twitter:



I did not intend to nitpick about the details of this particular study or to single out the authors. But the press release provided by the University of Pennsylvania Annenberg School for Communication is completely misleading (and poorly communicated).


Footnote

1 This is somewhat problematic, because you'd rather see each of the experimental conditions differ from the control condition.


Reference

Hepler J, & Albarracin D (2013). Complete unconscious control: Using (in)action primes to demonstrate completely unconscious activation of inhibitory control mechanisms. Cognition, 128 (3), 271-9 PMID: 23747649

Thursday, August 8, 2013

Possession Trance Disorder Caused by Door-to-Door Sales


Some companies and organizations that employ door-to-door sales tactics are known for their cult-like practices (e.g., Amway, traveling magazine sales, and Jehovah's Witnesses). An unusual psychiatric report included this religious brainwashing element in presenting the case of a 47 year old Japanese housewife who felt possessed by God after a visit by a door-to-door salesman (Saitoh et al., 1996):
In Japan, psychiatry has generally regarded the possessive state as symptomatic of religion- related mental disorders. ... Recently, there has been a proliferation of direct sales enterprises that incite anxiety in prospective customers in order to sell their products. Due to the prevalence of door-to-door peddling of items such as amulets and talismans to ward off curses and misfortune, the term ‘door-to-door sales’ has come to have a religious connotation.

Recently, we treated a case of possessive state accompanied with suicidal tendencies which are thought to have developed in connection with door-to-door sales. Religious factors and elements of brainwashing were seen both in the conditions that promoted the possessive state and in the state itself.

The patient grew up on a family farm in the Tokyo area. She was described as laconic, withdrawn, quiet, unsocial and nervous.
When the patient was 47 years old, a male she described as a ‘salesperson type’ came to her home in May. He read her palm and asked for her husband’s family name and birth date. When she gave him this information he predicted that some misfortune would befall her husband. The patient’s husband had fallen in an accident a few days earlier, and she became extremely anxious. The man then said, ‘I have a talisman, a lucky name chop (family seal) which will protect your husband from misfortune’. Although she was hesitant at first, she finally agreed... When she paid for the chop the man recommended that she go to a certain room in a hotel in Saitama prefecture for a more in-depth palm reading ... where she was one of 20 women who received a lecture on subjects such as lineage, marriage, health and happiness.

Approximately 1 week later, again at the salesman’s advice, she went to a rented room in a building in Tokyo where she received a scroll called a prayer book. At the same time she was urged to buy a sculpture which was called a ‘Fortune Tree’. Two days later she went to her bank with the salesman and a woman whom she did not know and paid the ¥5,400 000. The patient went to this room twice a month during June, July and August. The room was divided by a partition and she was shown biblical videotapes. In September, she complained of an inability to sleep, and stated, ‘I can hear God’s voice. He possesses me and is controlling my bodily movements’. Thereafter, she episodically gave orders to her family in an uninflected monotone, making unrealistic assertions such as, ‘Don’t eat that or you will die’ and ‘Don’t go out or you won’t come back’. In mid-September, she filed a complaint that she had been deceived into buying the ‘Fortune Tree’ at an exorbitant price. 

Shortly thereafter, she was taken to a private mental hospital and treated with the antipsychotic drug haloperidol. Two weeks later, she was able to recount her ordeal:
... ‘I felt like God had taken over my body. I was ordered by Him to do this or do that. Even if I wasn’t talking, my mouth just moved on its own. I didn’t go so far as to be One with God, but it was almost like that. That’s why I gave orders to my husband and child as though I were God’. The patient showed no subsequent objective signs of abnormality, and was released 2 months after admission.

The authors discussed her case in terms of the DSM-IV diagnosis, Dissociative Disorder Not Otherwise Specified, along with depressive symptoms and somatic complaints. Her attendance at the video lectures was described as a form of brainwashing. More specifically, her condition would fall under the category of Dissociative Trance Disorder (possession trance), a disturbance in consciousness or identity with a culturally specific element:
Dissociative trance involves narrowing of awareness of immediate surroundings or stereotyped behaviors or movements that are experienced as being beyond one's control. Possession trance involves replacement of the customary sense of personal identity by a new identity, attributed to the influence of a spirit, power, deity, or other person and associated with stereotyped involuntary movements or amnesia...

This case is rare not only because of its association with a business practice, but also because possession is usually seen in more isolated communities with traditional belief systems, quite unlike contemporary Tokyo.


Further Reading

Possession Trance Disorder in DSM-5


Reference

Satoh S, Obata S, Seno E, Okada T, Morita N, Saito T, Yoshikawa M, & Yamagami A (1996). A case of possessive state with onset influenced by 'door-to-door' sales. Psychiatry and clinical neurosciences, 50 (6), 313-6. PMID: 9014228

Friday, August 2, 2013

Breakthroughs in Bipolar Treatment

"We should continue to repurpose treatments and to recognise the role of serendipity" (Geddes & Miklowitz, 2013).

That quote was from a recent review article in The Lancet, which did not hint at any impending pharmacological breakthroughs in the treatment of bipolar disorder. In other words, the future of bipolar treatment doesn't look much different from the present (at least in the immediate term).

Bipolar disorder, an illness defined by the existence of manic or hypomanic highs, alternating with depressive lows, can be especially difficult to treat. And the mood episode known as a mixed state, where irritability, expansive mood, anxiety, and/or agitation occur simultaneously with depressive symptoms, is an under-recognized, moving-target diagnosis (Koukopoulos et al., 2013). Mood stabilizers such as lithium and divalproex have long been the first line pharmacological choices. But these don't always work, and polypharmacy seems to be the rule, rather than the exception.



The spinning molecule above is haloperidol, a first generation antipsychotic drug developed in 1958 and approved by the FDA in 1967 as a treatment for schizophrenia. It's a dopamine blocker known for producing untoward extrapyramidal side effects, or movement disorders such as tremors and tardive dyskinesia. Nonetheless, haloperidol (Haldol®) is still the most effective drug for the acute treatment of mania, and fairly well tolerated (see HAL in the figure below). The second generation (atypical) antipsychotics risperidone (RIS) and olanzapine (OLZ) also turn out pretty well in the antimanic sweepstakes. But these drugs can also have untoward side effects, notably substantial weight gain that can lead to high cholesterol, diabetes, and metabolic syndrome.



Figure (Geddes & Miklowitz, 2013). Ranking of antimanic drugs according to primary outcomes derived from multiple treatment meta-analysis. Efficacy is shown as a continuous outcome against the dropout rate. Treatments toward the red section combine the worst efficacy and tolerability profiles and treatments towards the green[ish] section combine the best profiles.1


Clearly, effective medications with fewer side effects are needed. Unfortunately, there doesn't seem to be anything new on the horizon, according to Geddes and Miklowitz:
Overall, advances in drug treatment remain quite modest. Antipsychotic drugs are effective in the acute treatment of mania; their efficacy in the treatment of depression is variable with the clearest evidence for quetiapine. Despite their widespread use, considerable uncertainty and controversy remains about the use of antidepressant drugs in the management of depressive episodes. Lithium has the strongest evidence for long-term relapse prevention; the evidence for anticonvulsants such as divalproex and lamotrigine is less robust and there is much uncertainty about the longer term benefits of antipsychotics.

The article is actually more bullish on combining existing drugs with various psychosocial interventions (e.g., family-focused approaches, strict regulation of social and circadian schedules, etc.), which are touched on below in the Appendix (Table 1 of Geddes & Miklowitz, 2013). That table also mentions some of the usual drug suspects.

To find out what else might be in the works, I looked through ClinicalTrials.gov for open interventional drug studies in adults. There were a few surprises... foremost among these was Methylphenidate for the Treatment of Acute Mania. It seems bizarre to me that methylphenidate (the stimulant drug Ritalin) would be proposed as a treatment for mania, since 40% of patients prescribed stimulants for bipolar depression (or comorbid ADHD) experienced stimulant-induced mania/hypomania (Wingo & Ghaemi, 2008).

The Ritalin trial was submitted to ClinicalTrials.gov in Feb. 2012, but the study is not yet open for patient recruitment 1.5 years later. The investigators recently published the study protocol in BMC Psychiatry, however (Kluge et al., 2013). They proposed the ‘vigilance regulation model of mania’ where:
Unstable vigilance induces a pathogenic circle with vigilance stabilisation syndrome leading to full-blown mania. [NOTE: huh?]

The outlined model ... is related to personality theories about extraversion [9] and sensation seeking [10] which comparably explain these traits as an attempt to compensate for low central nervous system arousal.

Basically, it works for ADHD, and there are a handful of uncontrolled case reports, so.... let's conduct a clinical trial.


Bipolar Depression

Depressive episodes in bipolar disorder are longer in duration and considered more difficult to treat. Again, ClinicalTrials.gov did not disappoint, revealing a grab bag of "repurposed" treatments:

Adjunctive Lisdexamfetamine - another stimulant for ADHD (aka Vyvanse).

Adjunctive Isradipine (a calcium channel blocker prescribed for high blood pressure) - this idea — not a new one — deserves a post of its own.

Adjunctive Minocycline (an antibiotic) - the proposed mechanism of action is to reduce the production of pro-inflammatory cytokines.

Ceftriaxone (another antibiotic) - however, the proposed mechanism here is inactivation of the excitatory neurotransmitter glutamate, via actions on the glutamate transporter.

NMDA Antagonists (i.e., club drug ketamine) - this is complicated and again deserving of its own post.

Tranylcypromine (a monoamine oxidase inhibitor) - old, old school antidepressant with lots of contraindications and dietary restrictions.

Ramelteon (a melatonin receptor agonist used to treat insomnia) - targeting the sleep/wake cycle could be an important approach.

N-Acetyl Cysteine and Aspirin - aspirin? really??
We propose to conduct a double-blind placebo-controlled trial with a widely available and prototypical non-steroidal anti-inflammatory agent, aspirin, and an antioxidant agent, NAC, involving symptomatic Bipolar Disorder type I and II patients having a depressive or mixed episode currently. This will be the first controlled study to test the hypothesis that aspirin and NAC, by themselves or in combination, will be beneficial in treating depression in bipolar disorder patients and in promoting mood stabilization.



For the ultimate in repurposed treatments, see this recent opinion piece in BMC Medicine on Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness.


Footnote

1 Abbreviations for Geddes and Miklowitz (2013) Figure:  ARI=aripiprazole. ASE=asenapine. CBZ=carbamazepine. VAL=valproate. GBT=gabapentin. HAL=haloperidol. LAM=lamotrigine. LIT=lithium. OLZ=olanzapine. PBO=placebo. QTP=quetiapine. RIS=risperidone. TOP=topiramate. ZIP=ziprasidone.


References

Berk M, Dean O, Drexhage H, McNeil JJ, Moylan S, Oneil A, Davey CG, Sanna L, & Maes M (2013). Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness. BMC medicine, 11 (1). PMID: 23506529

Geddes JR & Miklowitz DJ (2013). Treatment of bipolar disorder. Lancet, 381 (9878), 1672-82. PMID: 23663953

Kluge M, Hegerl U, Sander C, Dietzel J, Mergl R, Bitter I, Demyttenaere K, Gusmão R, Gonzalez-Pinto A, Perez-Sola V, Vieta E, Juckel G, Zimmermann US, Bauer M, Sienaert P, Quintão S, Edel MA, Bolyos C, Ayuso-Mateos JL, & López-García P (2013). Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate. BMC psychiatry, 13. PMID: 23446109

Koukopoulos A, Sani G, Ghaemi SN. (2013). Mixed features of depression: why DSM-5 is wrong (and so was DSM-IV). Br J Psychiatry 203:3-5.

Wingo AP, Ghaemi SN. (2008). Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients. Psychopharmacol Bull. 41:37-47.


Appendix

- click on image for a larger view -


Saturday, July 27, 2013

(De)Merit Badges for Non-Preregistered Research

Will Study Pre-Registration Be Good for Psychology?

There has been a lively debate recently about study pre-registration, a publishing model (or online repository) where detailed methodological and statistical plans for an experiment are registered in advance of data collection. The idea is to eliminate questionable research practices such as failing to report all of a study's dependent measures, deciding whether to collect more data after looking to see whether the results are significant, and selectively reporting studies that 'worked.'

Chris Chambers and Marcus Munafo wrote a widely discussed article that appeared in the Guardian:
Trust in science would be improved by study pre-registration

Open letter [with over 80 signatories]: We must encourage scientific journals to accept studies before the results are in

. . .

[The current] publishing culture is toxic to science. Recent studies have shown how intense career pressures encourage life scientists to engage in a range of questionable practices to generate publications – behaviours such as cherry-picking data or analyses that allow clear narratives to be presented, reinventing the aims of a study after it has finished to "predict" unexpected findings, and failing to ensure adequate statistical power. These are not the actions of a small minority; they are common, and result from the environment and incentive structures that most scientists work within.

The Open Science Framework, a movement for greater transparency in science, has developed merit badges to designate Open Data, Open Materials, and Preregistration.



The Open Data badge is earned for making publicly available the digitally shareable data necessary to reproduce the reported results.



The Open Materials badge is earned by making publicly available the components of the research methodology needed to reproduce the reported procedure and analysis.



The Preregistered badge is earned for having a preregistered design and analysis plan for the reported research and reporting results according to that plan. An analysis plan includes specification of the variables and the analyses that will be conducted.


One could imagine the introduction of two new demerit badges for Questionable and Rejected work.1



Questionable badges are issued when the committee suspects that questionable research practices have been used, as outlined in the paper by John et al. (2012).



The Rejected badge is earned when there is a suspicion that outright fraud may have occurred. This will typically spur an inquiry.


While an admirable goal, there may be aspects of this scheme that the proponents haven't fully considered.

Pre-registration would put science in chains

The pre-registration of study designs must be resisted, says Sophie Scott

. . .

...there are numerous problems with the idea. Limiting more speculative aspects of data interpretation risks making papers more one-dimensional in perspective. And the commitment to publish with the journal concerned would curtail researchers’ freedom to choose the most appropriate forum for their work after they have considered the results.

. . .

Moreover, in my fields (cognitive neuroscience and psychology), a significant proportion of studies would simply be impossible to run on a pre-registration model because many are not designed simply to test hypotheses. Some, for instance, are observational, while many of the participant populations introduce significant sources of complexity and noise; as introductions to psychology often point out, humans are very dirty test tubes.

One possible outcome is that certain types of research are privileged over others.2  The badge manifesto states that...
Badges do not define good practice, they certify that a particular practice was followed.

I find this assertion to be kind of hollow in the absence of badges issued for these other types of research, considered unsuitable for Preregistration. Therefore, in the spirit of fair play, I hereby introduce three new badges!



The Exploratory badge is issued to meritorious research that is not hypothesis-driven. This could include characterization of disease states and vast swaths of the neuroimaging literature ("Human Brain Mapping"), particularly in the early days. Not to mention the entire Human Connectome Project...



The Fishing Expedition badge can be earned by imaging studies that use exciting new methods like multi-voxel pattern analysis in neural decoding ("mind reading") applications, machine learning approaches to classify patient vs. control groups, and the latest in data mining ("Big Data").



The BRAIN Initiative badge is awarded by President Obama to research supported by his new $100 million Brain Research through Advancing Innovative Neurotechnologies Initiative. This bold new research effort will include advances in nanotechnology and purely exploratory efforts to record from thousands of neurons simultaneously.3



Additional Commentary on Study Pre-Registration

Sophie Scott has compiled the thoughts of researchers with varying degrees of opposition to pre-registration. Some are not totally opposed, but have questions on how it will be implemented and how it might be problematic for certain types of research. I fall into this latter camp.

The one current publication format for Registered Reports, in the journal Cortex, "guarantees publication of their future results providing that they adhere precisely to their registered protocol."

I'm not sure this would work in studies with children, patients, or other difficult populations, where everything is not always predictable in terms of task performance, nature of the brain response, etc. In my blurb on Sophie's blog, I said:

Another of your examples, neuropsychological case studies, is particularly difficult. Are you not supposed to test the rare individual with hemi-prosopagnosia or a unique form of synesthesia? Many aging and developmental studies could be problematic too. What if your elderly group is no better than chance in a memory test that undergrads could do at 80% accuracy? Maybe your small pilot sample of elderly were very high performers and not representative? Obviously, being locked into publishing such a study would set you back the time it would take to make the task easier and re-run the experiment. You could even say in the new paper that you ran the experiment with 500 items in the study list and the elderly were no better than chance. Who's to say that a reviewer would have caught that error in advance?

At any rate, I think it's important to have these kinds of discussions. And to freely distribute new kinds of badges.


Footnotes

1 Just to be clear, I made these up.

2 I'm not at all opposed to pre-registration, and I think it'll be an interesting experiment to see whether research practices improve and "scientific quality," or replicability, increases. But I can see the danger in that being viewed as "saintly" research with the rest of it tainted.

3 The Brain Activity Map as the Functional Connectome
To elucidate emergent levels of neural circuit function, we propose to record every action potential from every neuron within a circuit—a task we believe is feasible.

Monday, July 22, 2013

Rorschach inkblots and the neuroscientific basis for pareidolia

image via psychpsychbaby


A fascinating new historical article in the Journal of Neurology, Neurosurgery, and Psychiatry reviews the aesthetic and perceptual aspects of the Rorschach inkblots and proposes a role for them in understanding pareidolia, the phenomenon of ‘seeing’ objects in amorphous shapes (Schott, 2013). The Rorschach test was developed by handsome Swiss psychoanalyst Hermann Rorschach as a Psychodiagnostic method and only later used as a "projective test" thought to reveal unconscious psychopathology. Although still in use today, it has been widely discredited and shown to be an invalid instrument for assessing personality and mental illness (e.g., see What's Wrong With The Rorschach: Science Confronts the Controversial Inkblot Test).


Rorschach Card III via Wikipedia


Rorschach himself viewed the test as perceptual (p. 16 of Lemkau & Kronenberg's 1951 translation of Rorschach, 1921 - PDF):
Almost all subjects regard the experiment as a test of imagination. This conception is so general that it becomes, practically, a condition of the experiment. Nevertheless, the interpretation of the figures actually has little to do with imagination, and it is unnecessary to consider imagination a pre-requisite. ...

The interpretation of the chance forms falls in the field of perception and apperception rather than imagination.

Rorschach denied that it was projective in nature (p. 123, ibid):
The test cannot be considered as a means of delving into the unconscious. At best, it is far inferior to the other more profound psychological methods such as dream interpretation and association experiments. This is not difficult to understand. The test does not induce a «free flow from the subconscious» but requires adaptation to external stimuli, participation in the «fonction du réel».

Schott (2013) views the inkblots as both artistic entities (noting that Rorschach was a "gifted draughtsman and an excellent art critic") and as visual stimuli for scientific study. Perceptual features of the inkblots are considered in detail:
The pivotal graphic features which constitute the blots, and which give rise to the blots’ perceptual effects, include:
  • form: their amorphous shape
  • symmetry
  • the perception of movement: ‘Movement without Motion’
  • the blank spaces: figure–ground relationships
  • the use of colour
  • shading.

Finally, the article summarizes several neuroimaging experiments that have used the inkblots as stimuli. For example, Asari and colleagues reported that unusual or unique perceptions of the blots were associated with greater activation in the right temporal pole (2008) and with larger amygdala volumes (2010).




The Neuroscientific Basis for Pareidolia
Pareidolia is the phenomenon of perceiving a meaningful stimulus (such as a face or a hidden message) in fairly random everyday objects or sounds. We do have quite a propensity to see faces everywhere, and some religious people see the face of god (and other religious iconography) everywhere.

Schott (2013) concludes by suggesting that the images merit further investigation by neuroscientists for studies of pareidolia:
...these iconic ink-blots—which straddle iconography, psychology and neuroscience—deserve further study, and may yet illuminate important aspects of cerebral function, and even dysfunction.

But DO NOT use them to discriminate psychopaths from non-psychopaths in forensic populations (or for any other clinical diagnostic purpose, for that matter)...


References

Rorschach, H. (1921). Psychodiagnostics: A Diagnostic Test Based On Perception (1951 translation).

Schott, G.D. (2013). Revisiting the Rorschach ink-blots: from iconography and psychology to neuroscience. J Neurol Neurosurg Psychiatry DOI: 10.1136/jnnp-2013-305672

Wednesday, July 17, 2013

Jesus Christ and The Passion of Neuroscience

The case of the seriously confused book cover















Neuroscience, Neuropsychology, Neuropsychiatry, Behavioral Neurology: Emotion, Evolution, Development, Cognition, Language, Memory, Brain Damage, Consciousness, Abnormal Behavior
[Hardcover]
R. Joseph  (author)



This should be quite a read!!



Book Description

March 1, 2014 0974975540 978-0974975542

Right & Left Hemisphere Frontal Lobes Temporal Lobes Parietal Lobes Occipital Lobes Limbic System Limbic Language Memory, Hippocampus, & Amnesia Basal Ganglia: Striatum Brainstem Cerebellum


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link via ‏@hegelhegelhegel



But we might also have a seriously confused author.


R. Joseph is Rhawn Joseph...
...an advocate of directed panspermia and has developed his own hypothesis. He believes life did not originate on Earth but was transplanted to Earth by "cosmic seeds" encased in space debris 700 million years after the formation of the Earth. He claims that these genetic seeds filled with DNA contained the genetic instructions for the metamorphosis of all life, including woman and man. He also rejects the neo-Darwinian synthesis, instead replacing it with a form of non-Darwinian evolution which he describes as a "pre-determined evolutionary metamorphosis" which is pre-programmed in DNA of all life on earth.


Other masterworks by the same author:






His Geocities-era website simply must be seen to be believed: BrainMind.com

Here's his narcissistic list of publications.

The BrainMind.com Index (Neuroscience, Astrobiology, Quantum Physics).

Aliens.

Sex Differences. Females Have More Sex  [i.e., women are evil whores].

Evolution of Sexual Consciousness: Breasts, Buttocks & the Big Brain.


Wow. He is really a juvenile racist sexist homophobe. Don't waste your time.





Jesus Christ: The Passion--And the Gospels of Matthew, Mark, Luke & John 
[Hardcover] 
This is actually by R. Gabriel Joseph [Edited to add: apparently]


ADDENDUM (July 18, 2013): That ridiculous Evolution of Sexual Consciousness travesty was originally published in the "Journal" of Cosmology but later retracted due to "censorship" (only to reappear on Joseph's own site):

My porn is science, dammit!

In the summer of 2011, the journal published an article by Rhawn Joseph entitled "Sexual Consciousness: The Evolution of Breasts, Buttocks and the Big Brain". PZ Myers made fun[12] of the article's thesis and the random images of naked women that it contained. Apparently some other people were not happy about it either, because the article was retracted moved to Rhawn Joseph's personal site (BrainMind.com) and its original page got replaced with a whiny rant decrying censorship.[13]

Saturday, July 13, 2013

The Destructive Power of Shame


Shame is a negative self-conscious emotion that encompasses the feeling that something is terribly wrong with the self as a human being. Feelings of shame are a prominent factor in suicidal thoughts, behaviors, and self-harm (Hastings et al., 2002; Gilbert et al., 2010).  Lately I've encountered several articles saying that shame really isn't that bad for you, after all. The first theme of these commentaries is the spectacle of public shaming, and the second theme concerns private shame as a means of social control.


The Futility of Public Shaming

One news article bemoaned the end of shame in American politics. Sex scandals, drug use, and other egregious mistakes just don't have the same permanently negative consequences they used to. If you're a powerful male politician, that is.

Where’s the shame? Scandals may no longer end political careers 

WASHINGTON — Sex. Drugs. Cheating on a spouse.

Those words used to add up to shame. Put them in the same sentence as a politician’s name, and they ended careers.

Not anymore. The latest batch of unlikely back-from-the-swamp hopefuls are Anthony Weiner and Eliot Spitzer. Weiner resigned his New York City congressional seat two years ago after revelations that he’d tweeted a sexually suggestive picture of himself to a woman who was following him on Twitter. Spitzer left the state’s governorship in 2008 after reports surfaced that federal investigators had tagged him as “Client 9,” soliciting high-end prostitutes.

Read more here: http://www.mcclatchydc.com/2013/07/11/196452/wheres-the-shame-scandals-may.html#.UeG5e20rgdp#storylink=cpy

Here's the list of prominent male politicians from the article:

The lesson from all this: Wind up on the ever-increasing roll of tainted celebrities and re-emerge as the friendly, professional politician that vaulted you into office in the first place, and you’ll probably be OK.

"You'll probably be OK"... if you're a man. Has a female politician ever emerged intact from a federal sex scandal? Or has even been involved in such a scandal? If so, the double standard of slut shaming would likely put an end to her career. One of the few women on the state and local list is:
  • Minnesota Senate Majority Leader Amy Koch (R)... The married mother of one resigned from her leadership position and announced that she would not be seeking reelection shortly before four fellow Republicans indicated that she had been engaged in an "inappropriate" relationship with a male staffer. (2011).

Shaming on the Internet

How about for obnoxious offenders in the general public? Does the public shaming of those who spew idiotic sexist, racist, and homophobic comments on social media do any good?

The Public Shaming Tumblr aims to draw attention to bad actors on Twitter. Matt Binder says:
I started retweeting people complaining about welfare, food stamps, etc. and then following it up with a previous tweet of theirs that makes them look hypocritical/dumb/etc.

I discovered that as I would retweet these, my followers would start @replying these people and let them know they were idiots. They would then delete their offending tweet.

Well, I couldn’t let that happen. So, I screenshot away.

One continuous stream of vile sexist hatred was directed at Women's Wimbledon champion, Marion Bartoli. Why? Because she's not a blond model. Even BBC presenter John Inverdale took part in the insults, saying she "never going to be a looker"... to which Bartoli responded:
"It doesn't matter, honestly. I am not blonde, yes. That is a fact. Have I dreamt about having a model contract? No. I'm sorry. But have I dreamed about winning Wimbledon? Absolutely, yes."

This is the bottom line. She won Wimbledon, and her detractors will never accomplish anything that monumental. Does shaming the immature little boys for their pathetic cries for attention help anyone?


Some of those dudes deleted their accounts (to perhaps reappear another day), but others just go on their merry way with earth-shattering pronouncements like, "I have to untangle my earphones at least 3 times a day" and "Playstation is better than Xbox."

Public shaming doesn't seem to cause any lasting change. Does it?
Shaming: it’s a bit crap for everyone

It’s no surprise to anyone that Twitter and Facebook are filled with vile, racist, homophobic, bigoted awfulness. Because humanity is filled with vile, racist, homophobic bigots.
. . .

The consequence of these shaming sites, is that us “enlightened” folk then pile in on the bigots and abuse them and tell them how awful they are. And I’m willing to bet that the number of individuals who have rescinded what is probably years’ of built up bigotry is the same number of terrorist attacks that the Wellington airport security screeners have stopped: Zero.
. . .

That’s not to say we should let people get away with awfulness, but when we publicly name and shame and by proxy invite the internet to start tormenting these people, we are becoming them. No better than they are because we now have a figure to poke a stick at.

The shame sweepstakes become more costly and damaging once we enter the world of mental illness, addiction, and difference. Yet some still argue in favor of shaming.


Has there been a resurgence of shame as a means of social control?

1. Shame is good for you!  Shame is biological, so it's inevitable that those who are different or disabled will feel it. That was the premise of an article in the Atlantic, which in my opinion was complete and utter bullshit.

Challenging the Anti-Shame Zeitgeist

In response to a spate of teen suicides last year, a number of celebrities (Anne Hathaway, Justin Timberlake, Ellen DeGeneres, among others) used their visibility to castigate people who bully others. When public figures denounce bullying, they draw attention to the power of shame: A victim's experience at the hands of a bully can be so excruciating that life becomes unendurable.
. . .

Everywhere we look, pride is on the march, and shame is on the run.
. . .

If shame is such a bad thing, why did evolution see fit to program it into our genes? Evolutionary psychologists and sociobiologists believe that guilt and shame evolved to promote stable social relationships. According to the Oxford Encyclopedia of Evolution, "conformity to cultural values, beliefs, and practices makes behavior predictable and allows for the advent of complex coordination and cooperation." While the anti-shame zeitgeist views conformity to norms as oppressive, support for a great many of our social norms and the shame that enforces them is virtually unanimous.

For example, many would agree that fathers who walk out on their families, neglect their offspring, and fail to make child support payments should feel ashamed. Shame is the appropriate emotion for those men to feel: if powerful enough, the experience of shame might help them to fulfill their obligations as fathers and members of society.

Is there any scientific evidence that shaming deadbeat dads causes them to pay child support?

But it gets worse, with justifications for the biological and social inevitability of shame. Disabled children, little people, LGBT folks - be ashamed of yourselves! and stay in the closet.

While the efforts of all the parents in Solomon's book [Far From the Tree] to promote healthy self-esteem in their children are worthy and admirable, here is the unfortunate reality: those afflicted with a major disability will inevitably experience a sense of shame for the ways in which they are different, regardless of whether they have been shunned or actively shamed by their peers. Shame spontaneously arises from the perception of unfavorable difference, whether or not society inflicts it upon the person. 

Shame springs from the knowledge that your development didn't unfold as might have been expected under normal conditions.

So here it is, according to : if you're different in any way, you should feel ashamed for who you are. For simply existing in a less than perfect state. Because you are "pre-programmed" to feel that way.


Here's what I think: shame is a toxic social construction. It's used by religions to control the sexual behavior of their congregations. It's used by bullies to promote their social standing over the weak. It's used by parents to ostensibly make their children into high achievers, but they end up depressed, anxious, eating disordered. It's used by the media to make women (and men) so ashamed of their bodies that they go out and buy products to lose weight, improve their looks, enhance their private parts. Shame seems to hold a central role in the perception of an adverse self-image in young women with eating disorders (Franzoni et al., 2013).


2. Shame is good for you!  Addiction is a choice, so those who have a substance use disorder should be shamed into getting clean and sober. That was the territory covered in a 2007 Slate article by Sally Satel and Scott Lilienfeld, authors of Brainwashed: The Seductive Appeal of Mindless Neuroscience. An old blog post by Dirk Hanson at Addiction Inbox pointed me to their essay, which took exception to the notion that addiction is a brain disease:

Medical Misnomer
Addiction isn't a brain disease, Congress.

A full-scale campaign is under way to change the public perception of drug addiction, from a moral failing to a brain disease. Last spring, HBO aired an ambitious series that touted addiction as a "chronic and relapsing brain disease." In early July, a Time magazine cover story suggested that addiction is the doing of the neurotransmitter dopamine, which courses through the brain's reward circuits. And now Congress is weighing in.

They're opposed to the NIDA definition of drug addiction:
Addiction is defined as a chronic, relapsing brain disease that is characterized by compulsive drug seeking and use, despite harmful consequences. It is considered a brain disease because drugs change the brain; they change its structure and how it works. These brain changes can be long lasting and can lead to many harmful, often self-destructive, behaviors.

Satel and Lilienfeld continue:
Characterizing addiction as a brain disease misappropriates language more properly used to describe conditions such as multiple sclerosis or schizophrenia—afflictions that are neither brought on by sufferers themselves nor modifiable by their desire to be well. Also, the brain disease rhetoric is fatalistic, implying that users can never fully free themselves of their drug or alcohol problems. Finally, and most important, it threatens to obscure the vast role personal agency plays in perpetuating the cycle of use and relapse to drugs and alcohol. 

And now we get to their justification for shaming:
Finally, dare we ask: Why is stigma bad? It is surely unfortunate if it keeps people from getting help (although we believe the real issue is not embarrassment but fear of a breach of confidentiality). The push to destigmatize overlooks the healthy role that shame can play, by motivating many otherwise reluctant people to seek treatment in the first place and jolting others into quitting before they spiral down too far.

Really??? There is absolutely no evidence that shame motivates an addicted person to seek help. Quite the contrary, shame prevents people from getting the treatment they need (Wiechelt, 2007). Note that shame is different from guilt - with shame you're a bad person, and with guilt you did a bad thing. Why would shaming someone already filled with shame about their own undesirable behaviors be a motivating force for change?

Here's a straight answer from @maiasz
Being Ashamed of Drinking Prompts Relapse, Not Recovery

Embarrassment over an excessive-drinking session doesn’t necessarily lead to more sobriety.

In a study of alcoholics and relapse rates, researchers found that the more shame-ridden a drinker looked when talking about drinking — interpreted through body language like hunched shoulders — the more likely he or she was to relapse and the more drinks he or she downed during that relapse.
. . .

The results add to a body of literature suggesting that widely used shaming and humiliating methods of treating alcohol and other drug problems — such as those seen on shows like Celebrity Rehab — are not only ineffective but also may be counterproductive.

For example, a review of the research on the use of humiliating, confrontational tactics, which attempt to induce shame, found that none of the studies done in four decades supported this approach. In one study included in the analysis, the more the counselor confronted the client with past mistakes or other shaming information about his problem, the more the client drank.

So let's not challenge the anti-shame zeitgeist or encourage public shaming of those with addictions, mental illnesses, disabilities, or differences of any sort.


References

Franzoni E, Gualandi S, Caretti V, Schimmenti A, Di Pietro E, Pellegrini G, Craparo G, Franchi A, Verrotti A, Pellicciari A. (2013). The relationship between alexithymia, shame, trauma, and body image disorders: investigation over a large clinical sample. Neuropsychiatr Dis Treat. 9:185-93.

Gilbert P, McEwan K, Irons C, Bhundia R, Christie R, Broomhead C, & Rockliff H (2010). Self-harm in a mixed clinical population: the roles of self-criticism, shame, and social rank. The British journal of clinical psychology / the British Psychological Society, 49 (Pt 4), 563-76 PMID: 20109278

Hastings ME, Northman LM, Tangney JP (2002). Shame, Guilt, and Suicide. Suicide Science, 67-79 DOI: 10.1007/0-306-47233-3_6

Wiechelt SA (2007). The specter of shame in substance misuse. Substance use & misuse, 42 (2-3), 399-409 PMID: 17558937


Don't wait for pain
To find out you exist
Don't look for shame
Your better off without it
Life is unkind



Appendix

For other critiques of the "addiction is a brain disease" view, see Why Addiction is NOT a Brain Disease by Marc Lewis and Why the New Definition of Addiction, as ‘Brain Disease,’ Falls Short by Maia Szalavitz.1

But note that Lewis holds more nuanced views than his categorical statement indicates (e.g., "it's accurate in some ways"),2 and Szalavitz has reported on predispositions towards addiction that are based on pre-existing differences in brain structure.

Arguing that addiction is either completely a matter of choice or entirely caused by a faulty brain misses the complexity of a person with a brain in a social environment.


Footnotes

1 Szalavitz also says:
Like depression, addiction is a real medical disorder that affects the brain. But if we want to reduce the stigma associated with it, emphasizing recovery and resilience is probably more useful than focusing on definitions of brain disease.

2 The entire paragraph from Lewis is worth quoting:
What’s wrong with this definition?

It’s accurate in some ways. It accounts for the neurobiology of addiction better than the “choice” model and other contenders. It explains the helplessness addicts feel: they are in the grip of a disease, and so they can’t get better by themselves. It also helps alleviate guilt, shame, and blame, and it gets people on track to seek treatment. Moreover, addiction is indeed like a disease, and a good metaphor and a good model may not be so different.